Role of Uncoupling Protein-2 Up-Regulation and Triglyceride Accumulation in Impaired Glucose- Stimulated Insulin Secretion in a -Cell Lipotoxicity Model Overexpressing Sterol Regulatory Element- Binding Protein-1c
نویسندگان
چکیده
Departments of Metabolic Diseases (T.Y., K.E., Y.O., S.Y., T.Y., N.S., T.K.) and Cardiovascular Medicine (R.N.), University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan; CREST of Japan Science and Technology Corp. (K.E., Y.O., T.Y., M.N., T.K.), Saitama 332-0012, Japan; National Institute of Health and Nutrition (M.N., T.K.), Tokyo 162-8636, Japan; and Institute for Diabetes Care and Research, Asahi Life Foundation (M.N.), Tokyo 100-0005, Japan
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Cholesterol accumulation and diabetes in pancreatic b-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity
To determine the role of cholesterol synthesis in pancreatic b-cells, a transgenic model of in vivo activation of sterol-regulatory element binding protein 2 (SREBP-2) specifically in b-cells (TgRIP-SREBP-2) was developed and analyzed. Expression of nuclear human SREBP-2 in b-cells resulted in severe diabetes as evidenced by greater than 5-fold elevations in glycohemoglobin compared with C57BL/...
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